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What is Hydrocodone
Other names; Hydrocodeinone, hydrocodone, hydrocone, Tabs, Vics, Vicos, 357s.
Hydrocodone belongs to the family of medicines called Narcotic analgegesics (pain medicine), which acts on the central nervous system and acts as a pain relieve. It is a semi synthetic opioid drug which is derived from the opiate Codeine. It is semi synthetic ,which implies it is chemically made by altering a naturally occurring substance that is derived from the opiuim poppy which in this case is codeine. This is because hydrocodone is far better than and potent than codeine.
Importance of the drug:
This drug is a semi – synthetic hydro generated codeine derivative and opioid agonist which with anelgesic and antitusive effects. It binds to and activates the MU receptors in the CNS , this leads to analgesia, euphoria, respiratory depression, mitosis, decreased gastrointestinal motility, suppression and physical dependence.
Hydrocodone is concerted to hydromorphone by the cytochrome P450 enzyme Cyp2D6. It is strong pain relieve for both mild to severe pain.
Side effects ( opioids)
When hydrocodone is consumed for a long period of time, it may become habbut forming leafing to mental or physical dependence. Addiction, Respiratory suppression, overdose and eventual death. Sedation, impaired cognition, and mood change.
Hydrocodone is highly addictive and contributes to the opioid crisis in the united States of America. People become addicted to hydrocodone and other opioids owing to its effect on the brain reward’s system. This is because opioids release neurotransmitters in large volumes and the reward is a feeling of pleasure and excitement which of course is the genesis of addiction.
Overdosing may lead to liver damage.
Memory loss, powerful hallucination and at times temporal madness may result.
Hydrocodone is a prescription opioid drug with two FDA approved clinical uses which are
- I) Pain Relieve and
- ii) Cough suppression.
As a pain reliever, it is used to manage both moderate to severe pain when all other alternative pain treatment options are found inadequate or unacceptable . According to the CDC guidelines , hydrocodone can be used in the following cases;
* Chronic , non cancer pain ( pain lasting more than three months) , End of life Care, Cancer pain.
It can be used alone or in combination with other medications or non productive cough. ie a cough without Phlegm coming up.
Should be administered following the lowest possible amount to achieve reasonable pain control. The drug should be taken every four to six hours and the starting dose for adults is usually 2’5mg.
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